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BMPR2 mutations and survival in pulmonary arterial hypertension: An individual participant data meta-analysis
Abstract
Pulmonary arterial hypertension (PAH) is a rare disorder characterised by progressive remodelling of the small pulmonary arteries, resulting in increased pulmonary vascular resistance and ultimately right ventricular failure and death.[1,2] The diagnosis of PAH requires a mean pulmonary artery pressure of 25 mmHg or more with a pulmonary artery wedge pressure of 15 mmHg or less at right heart catheterisation in the absence of chronic thromboembolic, left heart or respiratory disease.
Author's affiliations
T Mnguni, Senior Registrar in Pulmonology, Groote Schuur Hospital and University of Cape Town, South Africa
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Article History
Date published: 2016-12-19
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African Journal of Thoracic and Critical Care Medicine| Online ISSN: 2617-0205
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