Correspondence: Cases

Methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia

M Agarwal, K K Sharma, K Deokar, N Bharti

Abstract


Methotrexate, an immunomodulatory agent used for a wide variety of indications, can cause pulmonary toxicity in the form of pneumonitis, organising pneumonia, pulmonary fibrosis, pleural effusion, pulmonary infections or lymphoproliferative disease. We report a case of methotrexate pneumonitis in a patient with gestational trophoblastic neoplasia. The diagnosis of methotrexate pneumonitis is challenging, as the signs and symptoms can be caused by intercurrent infection, concomitant medications or an underlying disease condition. A high index of suspicion is required for diagnosis. Management consists of drug discontinuation and steroids in patients with respiratory failure

Authors' affiliations

M Agarwal, Department of Pulmonary Medicine, Eternal Hospital Care Center, Jaipur, Rajasthan, India

K K Sharma, Department of Pulmonary Medicine, Eternal Hospital Care Center, Jaipur, Rajasthan, India

K Deokar, Department of Pulmonary Medicine, Sapphire Hospitals, Thane, Maharashtra, India

N Bharti, Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

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Cite this article

African Journal of Thoracic and Critical Care Medicine 2022;28(3):133-134.

Article History

Date submitted: 2022-09-16
Date published: 2022-09-16

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African Journal of Thoracic and Critical Care Medicine| Online ISSN: 2617-0205

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